Glaessl A, Bosserhoff AK, Buettner R, Hohenleutner U, Landthaler M, Stolz W
Key findings include: (1) Diverse Mechanisms : Plants like cinnamon (cinnamaldehyde), bitter melon (karavilagenine E), and ginseng (ginsenosides) modulate GLP-1 via DPP-4 inhibition, receptor activation, and SCFA production, offering multi-targeted effects beyond glucose control
Lifestyle Factors: Sleep, Stress, and Cortisol Poor sleep and chronic stress boost cortisol, a hormone that promotes fat storage, particularly around the midsection
GLP-1 agonists (semaglutide, dulaglutide, liraglutide) are injectable or oral medications for type 2 diabetes and weight management that mimic natural GLP-1 hormone
Such developments could expand Metformins clinical utility and address some of its current limitations